Endogenous superantigens shape response to exogenous superantigens.
نویسندگان
چکیده
Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vbeta8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vbeta8(+) T cells, was significantly reduced and conferred protection from superantigen-induced mortality.
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ورودعنوان ژورنال:
- Clinical and diagnostic laboratory immunology
دوره 12 9 شماره
صفحات -
تاریخ انتشار 2005